Drug interactions
Ranolazine + Tamsulosin
Severity: Minor
Ranolazine and Tamsulosin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ranolazine weakly inhibits CYP2D6 and CYP3A4 and may slightly raise tamsulosin exposure. Both can cause dizziness and hypotension.
What this interaction means in plain words
Ranolazine and Tamsulosin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ranolazine belongs to Cardiovascular; Tamsulosin belongs to Genitourinary.
Why it happens
Ranolazine weakly inhibits CYP2D6 and CYP3A4, reducing tamsulosin clearance.
What to do
Monitor blood pressure and dizziness after starting ranolazine. Adjust the tamsulosin dose if symptoms occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tamsulosin
- Alfuzosin + Tamsulosin Major
- Avanafil + Tamsulosin Major
- Ceritinib + Tamsulosin Major
- Clarithromycin + Tamsulosin Major
- Cobicistat + Tamsulosin Major
- Doxazosin + Tamsulosin Major
Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Frequently asked questions
Can I take Ranolazine with Tamsulosin?
MediHelp rates the interaction as minor. Ranolazine and Tamsulosin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ranolazine weakly inhibits CYP2D6 and CYP3A4 and may slightly raise tamsulosin exposure. Both can cause dizziness and hypotension.
How serious is the interaction between Ranolazine and Tamsulosin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and dizziness after starting ranolazine. Adjust the tamsulosin dose if symptoms occur.
What other medicines interact with Tamsulosin?
MediHelp also lists interactions of Tamsulosin with, for example, Alfuzosin, Avanafil, Ceritinib. The full list is on the Tamsulosin page.
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