Drug interactions
Ranolazine + Verapamil
Severity: Moderate
Ranolazine and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil, a moderate CYP3A4 and P-glycoprotein inhibitor, increases ranolazine exposure. Higher ranolazine levels can cause dizziness, nausea and QT prolongation.
What this interaction means in plain words
Ranolazine and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ranolazine belongs to Cardiovascular; Verapamil belongs to Cardiovascular.
Why it happens
Inhibition of CYP3A4 and P-glycoprotein, reducing ranolazine clearance.
What to do
Titrate ranolazine according to response and limit the dose as labeling advises with moderate CYP3A4 inhibitors. Monitor for adverse effects and QT prolongation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Frequently asked questions
Can I take Ranolazine with Verapamil?
MediHelp rates the interaction as moderate. Ranolazine and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Verapamil, a moderate CYP3A4 and P-glycoprotein inhibitor, increases ranolazine exposure. Higher ranolazine levels can cause dizziness, nausea and QT prolongation.
How serious is the interaction between Ranolazine and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate ranolazine according to response and limit the dose as labeling advises with moderate CYP3A4 inhibitors. Monitor for adverse effects and QT prolongation.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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