Drug interactions
Ranolazine + Vinblastine
Severity: Moderate
Ranolazine and Vinblastine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ranolazine may increase vinblastine exposure by inhibiting P-glycoprotein efflux. Greater exposure could worsen myelosuppression and neurotoxicity.
What this interaction means in plain words
Ranolazine and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ranolazine belongs to Cardiovascular; Vinblastine belongs to Oncology.
Why it happens
Ranolazine inhibits P-glycoprotein, reducing vinblastine efflux and clearance.
What to do
Monitor blood counts and neurologic status more closely during combined use. Consider an alternative antianginal if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Other interactions of Vinblastine
Frequently asked questions
Can I take Ranolazine with Vinblastine?
MediHelp rates the interaction as moderate. Ranolazine and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ranolazine may increase vinblastine exposure by inhibiting P-glycoprotein efflux. Greater exposure could worsen myelosuppression and neurotoxicity.
How serious is the interaction between Ranolazine and Vinblastine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and neurologic status more closely during combined use. Consider an alternative antianginal if toxicity develops.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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