Drug interactions
Ranolazine + Voclosporin
Severity: Moderate
Ranolazine and Voclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin can prolong the QT interval at supratherapeutic doses, and ranolazine also has QT effects. Ranolazine inhibits P-gp and weakly CYP3A, which could also raise voclosporin exposure and risk of nephrotoxicity.
What this interaction means in plain words
Ranolazine and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ranolazine belongs to Cardiovascular; Voclosporin belongs to Miscellaneous.
Why it happens
Additive QT prolongation, plus possible P-gp and weak CYP3A inhibition by ranolazine increasing voclosporin levels.
What to do
Monitor ECG, renal function and blood pressure. Correct potassium and magnesium abnormalities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Ranolazine with Voclosporin?
MediHelp rates the interaction as moderate. Ranolazine and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voclosporin can prolong the QT interval at supratherapeutic doses, and ranolazine also has QT effects. Ranolazine inhibits P-gp and weakly CYP3A, which could also raise voclosporin exposure and risk of nephrotoxicity.
How serious is the interaction between Ranolazine and Voclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG, renal function and blood pressure. Correct potassium and magnesium abnormalities.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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