Drug interactions
Rasagiline + Teriflunomide
Severity: Minor
Rasagiline and Teriflunomide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Teriflunomide is a weak inducer of CYP1A2 and may modestly lower exposure to CYP1A2 substrates such as rasagiline. Reduced rasagiline levels could diminish its antiparkinsonian effect. The effect is generally small.
What this interaction means in plain words
Rasagiline and Teriflunomide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Rasagiline belongs to Central Nervous System; Teriflunomide belongs to Central Nervous System.
Why it happens
Teriflunomide weakly induces CYP1A2, increasing the metabolism of rasagiline.
What to do
Monitor motor symptom control after teriflunomide is started. Increase rasagiline within the labeled dose range only if efficacy is clearly lost.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Other interactions of Teriflunomide
Frequently asked questions
Can I take Rasagiline with Teriflunomide?
MediHelp rates the interaction as minor. Rasagiline and Teriflunomide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Teriflunomide is a weak inducer of CYP1A2 and may modestly lower exposure to CYP1A2 substrates such as rasagiline. Reduced rasagiline levels could diminish its antiparkinsonian effect. The effect is generally small.
How serious is the interaction between Rasagiline and Teriflunomide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor motor symptom control after teriflunomide is started. Increase rasagiline within the labeled dose range only if efficacy is clearly lost.
What other medicines interact with Rasagiline?
MediHelp also lists interactions of Rasagiline with, for example, Atomoxetine, Brimonidine, Bupropion-naltrexone. The full list is on the Rasagiline page.
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