Drug interactions
Regorafenib + Sofosbuvir
Severity: Minor
Regorafenib and Sofosbuvir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sofosbuvir is a substrate of the efflux transporters P-gp and BCRP, and regorafenib is thought to inhibit BCRP. Higher sofosbuvir exposure is therefore possible, though the clinical impact is probably small.
What this interaction means in plain words
Regorafenib and Sofosbuvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Regorafenib belongs to Oncology; Sofosbuvir belongs to Anti Virals.
Why it happens
Regorafenib inhibition of BCRP may reduce efflux of sofosbuvir and increase its exposure.
What to do
No empirical dose adjustment is required; monitor for sofosbuvir adverse effects and treatment response during coadministration.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sofosbuvir
Other interactions of Regorafenib
Frequently asked questions
Can I take Regorafenib with Sofosbuvir?
MediHelp rates the interaction as minor. Regorafenib and Sofosbuvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sofosbuvir is a substrate of the efflux transporters P-gp and BCRP, and regorafenib is thought to inhibit BCRP. Higher sofosbuvir exposure is therefore possible, though the clinical impact is probably small.
How serious is the interaction between Regorafenib and Sofosbuvir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose adjustment is required; monitor for sofosbuvir adverse effects and treatment response during coadministration.
What other medicines interact with Sofosbuvir?
MediHelp also lists interactions of Sofosbuvir with, for example, Amiodarone, Apalutamide, Carbamazepine. The full list is on the Sofosbuvir page.
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