Drug interactions
Regorafenib + Stiripentol
Severity: Moderate
Regorafenib and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol both inhibits and induces CYP3A4, so regorafenib exposure may change in either direction. This may lead to toxicity or reduced efficacy.
What this interaction means in plain words
Regorafenib and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Regorafenib belongs to Oncology; Stiripentol belongs to Central Nervous System.
Why it happens
Stiripentol modulates CYP3A4 through mixed inhibition and induction, altering regorafenib metabolism.
What to do
Monitor regorafenib tolerability and response, and adjust dose accordingly. Check liver function regularly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Regorafenib
Other interactions of Stiripentol
Frequently asked questions
Can I take Regorafenib with Stiripentol?
MediHelp rates the interaction as moderate. Regorafenib and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol both inhibits and induces CYP3A4, so regorafenib exposure may change in either direction. This may lead to toxicity or reduced efficacy.
How serious is the interaction between Regorafenib and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor regorafenib tolerability and response, and adjust dose accordingly. Check liver function regularly.
What other medicines interact with Regorafenib?
MediHelp also lists interactions of Regorafenib with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Regorafenib page.
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