Drug interactions
Repaglinide + Repotrectinib
Severity: Moderate
Repaglinide and Repotrectinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Repotrectinib induces CYP3A4 and may lower repaglinide concentrations. This can lead to hyperglycemia from reduced efficacy.
What this interaction means in plain words
Repaglinide and Repotrectinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Repaglinide belongs to Endocrine; Repotrectinib belongs to Oncology.
Why it happens
Repotrectinib induces CYP3A4, increasing repaglinide metabolism.
What to do
Monitor blood glucose and titrate repaglinide upward or switch to an agent not dependent on CYP3A4 if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporine + Repaglinide Major
- Cyclosporin + Repaglinide Major
Other interactions of Repotrectinib
- Apalutamide + Repotrectinib Contraindicated
- Amiodarone + Repotrectinib Major
- Amobarbital + Repotrectinib Major
- Aprepitant + Repotrectinib Major
- Armodafinil + Repotrectinib Major
- Bosentan + Repotrectinib Major
Frequently asked questions
Can I take Repaglinide with Repotrectinib?
MediHelp rates the interaction as moderate. Repaglinide and Repotrectinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Repotrectinib induces CYP3A4 and may lower repaglinide concentrations. This can lead to hyperglycemia from reduced efficacy.
How serious is the interaction between Repaglinide and Repotrectinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and titrate repaglinide upward or switch to an agent not dependent on CYP3A4 if control worsens.
What other medicines interact with Repaglinide?
MediHelp also lists interactions of Repaglinide with, for example, Gemfibrozil, Clarithromycin, Clopidogrel. The full list is on the Repaglinide page.
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