Drug interactions
Repaglinide + Risperidone
Severity: Moderate
Repaglinide and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Risperidone may raise blood glucose and cause insulin resistance, which can reduce the effectiveness of repaglinide. Glycemic control may worsen.
What this interaction means in plain words
Repaglinide and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Repaglinide belongs to Endocrine; Risperidone belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism: antipsychotic-induced insulin resistance opposes glucose lowering.
What to do
Monitor blood glucose and HbA1c, and adjust the repaglinide dose or add therapy if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporine + Repaglinide Major
- Cyclosporin + Repaglinide Major
Frequently asked questions
Can I take Repaglinide with Risperidone?
MediHelp rates the interaction as moderate. Repaglinide and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Risperidone may raise blood glucose and cause insulin resistance, which can reduce the effectiveness of repaglinide. Glycemic control may worsen.
How serious is the interaction between Repaglinide and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c, and adjust the repaglinide dose or add therapy if control worsens.
What other medicines interact with Risperidone?
MediHelp also lists interactions of Risperidone with, for example, Ibutilide, Vandetanib, Adagrasib. The full list is on the Risperidone page.
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