Drug interactions
Repotrectinib + Sertraline
Severity: Minor
Repotrectinib and Sertraline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Repotrectinib is metabolized by CYP3A4, and sertraline is at most a weak inhibitor of this enzyme. Any increase in repotrectinib exposure is therefore expected to be small and is not clinically established. The labeling restriction applies to strong and moderate CYP3A inhibitors.
What this interaction means in plain words
Repotrectinib and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Repotrectinib belongs to Oncology; Sertraline belongs to Central Nervous System.
Why it happens
Weak CYP3A4 inhibition by sertraline may slightly raise repotrectinib exposure; clinical significance not established.
What to do
No dose change is generally needed. Monitor for repotrectinib adverse effects such as dizziness, ataxia and cognitive effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Repotrectinib
- Apalutamide + Repotrectinib Contraindicated
- Amiodarone + Repotrectinib Major
- Amobarbital + Repotrectinib Major
- Aprepitant + Repotrectinib Major
- Armodafinil + Repotrectinib Major
- Bosentan + Repotrectinib Major
Frequently asked questions
Can I take Repotrectinib with Sertraline?
MediHelp rates the interaction as minor. Repotrectinib and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Repotrectinib is metabolized by CYP3A4, and sertraline is at most a weak inhibitor of this enzyme. Any increase in repotrectinib exposure is therefore expected to be small and is not clinically established. The labeling restriction applies to strong and moderate CYP3A inhibitors.
How serious is the interaction between Repotrectinib and Sertraline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed. Monitor for repotrectinib adverse effects such as dizziness, ataxia and cognitive effects.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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