Drug interactions
Repotrectinib + Thioridazine
Severity: Moderate
Repotrectinib and Thioridazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Repotrectinib induces CYP3A4 and may lower concentrations of CYP3A substrates. Thioridazine is mainly metabolized by CYP2D6, so a loss of effect is possible but its importance is uncertain; induction could also alter metabolite formation.
What this interaction means in plain words
Repotrectinib and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Repotrectinib belongs to Oncology; Thioridazine belongs to Central Nervous System.
Why it happens
CYP3A4 induction by repotrectinib may reduce thioridazine exposure, though CYP3A4 is a minor pathway.
What to do
Monitor psychiatric response and adjust the thioridazine dose if efficacy declines. Consider an alternative antipsychotic if control is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Other interactions of Repotrectinib
- Apalutamide + Repotrectinib Contraindicated
- Amiodarone + Repotrectinib Major
- Amobarbital + Repotrectinib Major
- Aprepitant + Repotrectinib Major
- Armodafinil + Repotrectinib Major
- Bosentan + Repotrectinib Major
Frequently asked questions
Can I take Repotrectinib with Thioridazine?
MediHelp rates the interaction as moderate. Repotrectinib and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Repotrectinib induces CYP3A4 and may lower concentrations of CYP3A substrates. Thioridazine is mainly metabolized by CYP2D6, so a loss of effect is possible but its importance is uncertain; induction could also alter metabolite formation.
How serious is the interaction between Repotrectinib and Thioridazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor psychiatric response and adjust the thioridazine dose if efficacy declines. Consider an alternative antipsychotic if control is lost.
What other medicines interact with Thioridazine?
MediHelp also lists interactions of Thioridazine with, for example, Abiraterone, Adagrasib, Amiodarone. The full list is on the Thioridazine page.
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