Drug interactions
Repotrectinib + Ticagrelor
Severity: Moderate
Repotrectinib and Ticagrelor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ticagrelor inhibits P-glycoprotein and could raise repotrectinib exposure, but the clinical relevance is uncertain and the effect is predicted rather than demonstrated. Higher repotrectinib levels could worsen dose-related adverse effects such as dizziness, ataxia and neurotoxicity.
What this interaction means in plain words
Repotrectinib and Ticagrelor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Repotrectinib belongs to Oncology; Ticagrelor belongs to Cardiovascular.
Why it happens
Ticagrelor inhibits intestinal P-glycoprotein efflux, potentially increasing repotrectinib absorption.
What to do
Monitor for repotrectinib neurologic adverse effects such as dizziness and ataxia, and reduce the dose if they emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ticagrelor
- Itraconazole + Ticagrelor Contraindicated
- Ketoconazole + Ticagrelor Contraindicated
- Levoketoconazole + Ticagrelor Contraindicated
- Abciximab + Ticagrelor Major
- Abrocitinib + Ticagrelor Major
- Acalabrutinib + Ticagrelor Major
Other interactions of Repotrectinib
- Apalutamide + Repotrectinib Contraindicated
- Amiodarone + Repotrectinib Major
- Amobarbital + Repotrectinib Major
- Aprepitant + Repotrectinib Major
- Armodafinil + Repotrectinib Major
- Bosentan + Repotrectinib Major
Frequently asked questions
Can I take Repotrectinib with Ticagrelor?
MediHelp rates the interaction as moderate. Repotrectinib and Ticagrelor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ticagrelor inhibits P-glycoprotein and could raise repotrectinib exposure, but the clinical relevance is uncertain and the effect is predicted rather than demonstrated. Higher repotrectinib levels could worsen dose-related adverse effects such as dizziness, ataxia and neurotoxicity.
How serious is the interaction between Repotrectinib and Ticagrelor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for repotrectinib neurologic adverse effects such as dizziness and ataxia, and reduce the dose if they emerge.
What other medicines interact with Ticagrelor?
MediHelp also lists interactions of Ticagrelor with, for example, Itraconazole, Ketoconazole, Levoketoconazole. The full list is on the Ticagrelor page.
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