Drug interactions
Repotrectinib + Valproic acid
Severity: Moderate
Repotrectinib and Valproic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Repotrectinib induces CYP3A4 and other metabolic enzymes and may lower valproate concentrations. Valproate is cleared mainly by glucuronidation and mitochondrial beta-oxidation, with a smaller CYP contribution, so the effect is probably modest. Loss of seizure or mood control is still possible.
What this interaction means in plain words
Repotrectinib and Valproic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Repotrectinib belongs to Oncology; Valproic acid belongs to Central Nervous System.
Why it happens
Enzyme induction by repotrectinib may increase valproate clearance, though CYP3A4 is only a minor route for valproate.
What to do
Measure serum valproate concentrations after repotrectinib is started and adjust the valproate dose according to the level and clinical response. Watch for breakthrough seizures or loss of mood control.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Valproic acid
- Ertapenem + Valproic acid Contraindicated
- Imipenem / cilastatin / relebactam + Valproic acid Contraindicated
- Imipenem / cilastatin + Valproic acid Contraindicated
- Meropenem / vaborbactam + Valproic acid Contraindicated
- Meropenem + Valproic acid Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Valproic acid Major
Other interactions of Repotrectinib
- Apalutamide + Repotrectinib Contraindicated
- Amiodarone + Repotrectinib Major
- Amobarbital + Repotrectinib Major
- Aprepitant + Repotrectinib Major
- Armodafinil + Repotrectinib Major
- Bosentan + Repotrectinib Major
Frequently asked questions
Can I take Repotrectinib with Valproic acid?
MediHelp rates the interaction as moderate. Repotrectinib and Valproic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Repotrectinib induces CYP3A4 and other metabolic enzymes and may lower valproate concentrations. Valproate is cleared mainly by glucuronidation and mitochondrial beta-oxidation, with a smaller CYP contribution, so the effect is probably modest. Loss of seizure or mood control is still possible.
How serious is the interaction between Repotrectinib and Valproic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Measure serum valproate concentrations after repotrectinib is started and adjust the valproate dose according to the level and clinical response. Watch for breakthrough seizures or loss of mood control.
What other medicines interact with Valproic acid?
MediHelp also lists interactions of Valproic acid with, for example, Ertapenem, Imipenem / cilastatin / relebactam, Imipenem / cilastatin. The full list is on the Valproic acid page.
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