Drug interactions
Revefenacin + Sofosbuvir-velpatasvir-voxilaprevir
Severity: Moderate
Revefenacin and Sofosbuvir-velpatasvir-voxilaprevir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Velpatasvir and voxilaprevir inhibit OATP1B1/1B3, which transport revefenacin's active metabolite. Systemic exposure to this metabolite may increase, though inhaled revefenacin has low systemic exposure. Labeling recommends against combining OATP inhibitors with revefenacin.
What this interaction means in plain words
Revefenacin and Sofosbuvir-velpatasvir-voxilaprevir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Revefenacin belongs to Respiratory; Sofosbuvir-velpatasvir-voxilaprevir belongs to Anti Virals.
Why it happens
Inhibition of OATP1B1/1B3 uptake by velpatasvir and voxilaprevir increases revefenacin active metabolite exposure.
What to do
Consider an alternative long-acting bronchodilator during HCV treatment. If coadministered, monitor for anticholinergic effects such as dry mouth and urinary retention.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sofosbuvir-velpatasvir-voxilaprevir
- Fosphenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Phenobarbital + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Phenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Rifampin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Other interactions of Revefenacin
- Cyclosporin + Revefenacin Major
- Indacaterol-glycopyrronium + Revefenacin Major
- Revefenacin + Rifampicin Major
- Revefenacin + Tiotropium Major
- Atropine + Revefenacin Moderate
- Benztropine + Revefenacin Moderate
Frequently asked questions
Can I take Revefenacin with Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp rates the interaction as moderate. Revefenacin and Sofosbuvir-velpatasvir-voxilaprevir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Velpatasvir and voxilaprevir inhibit OATP1B1/1B3, which transport revefenacin's active metabolite. Systemic exposure to this metabolite may increase, though inhaled revefenacin has low systemic exposure. Labeling recommends against combining OATP inhibitors with revefenacin.
How serious is the interaction between Revefenacin and Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an alternative long-acting bronchodilator during HCV treatment. If coadministered, monitor for anticholinergic effects such as dry mouth and urinary retention.
What other medicines interact with Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir-voxilaprevir with, for example, Fosphenytoin, Phenobarbital, Phenytoin. The full list is on the Sofosbuvir-velpatasvir-voxilaprevir page.
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