Drug interactions
Revefenacin + Solifenacin
Severity: Moderate
Revefenacin and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have antimuscarinic activity, so combined use may add to anticholinergic effects such as dry mouth, constipation, urinary retention and blurred vision. Revefenacin is inhaled with low systemic exposure, so effects are usually modest.
What this interaction means in plain words
Revefenacin and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Revefenacin belongs to Respiratory; Solifenacin belongs to Genitourinary.
Why it happens
Additive antagonism at muscarinic receptors.
What to do
Monitor for urinary retention, constipation, dry mouth and worsening narrow-angle glaucoma. Reduce or stop one drug if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Other interactions of Revefenacin
- Cyclosporin + Revefenacin Major
- Indacaterol-glycopyrronium + Revefenacin Major
- Revefenacin + Rifampicin Major
- Revefenacin + Tiotropium Major
- Atropine + Revefenacin Moderate
- Benztropine + Revefenacin Moderate
Frequently asked questions
Can I take Revefenacin with Solifenacin?
MediHelp rates the interaction as moderate. Revefenacin and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have antimuscarinic activity, so combined use may add to anticholinergic effects such as dry mouth, constipation, urinary retention and blurred vision. Revefenacin is inhaled with low systemic exposure, so effects are usually modest.
How serious is the interaction between Revefenacin and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for urinary retention, constipation, dry mouth and worsening narrow-angle glaucoma. Reduce or stop one drug if symptoms develop.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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