Drug interactions
Ribociclib + Solifenacin
Severity: Major
Ribociclib and Solifenacin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib causes concentration-dependent QT prolongation, and it is also a moderate-to-strong CYP3A4 inhibitor that can raise solifenacin levels. Both effects increase the chance of QT-related arrhythmia.
What this interaction means in plain words
Ribociclib and Solifenacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ribociclib belongs to Oncology; Solifenacin belongs to Genitourinary.
Why it happens
Additive QT prolongation plus CYP3A4 inhibition by ribociclib increasing solifenacin exposure.
What to do
Avoid the combination where possible. If needed, cap solifenacin at 5 mg daily and monitor the ECG and electrolytes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Solifenacin
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Ribociclib with Solifenacin?
MediHelp rates the interaction as major. Ribociclib and Solifenacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ribociclib causes concentration-dependent QT prolongation, and it is also a moderate-to-strong CYP3A4 inhibitor that can raise solifenacin levels. Both effects increase the chance of QT-related arrhythmia.
How serious is the interaction between Ribociclib and Solifenacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If needed, cap solifenacin at 5 mg daily and monitor the ECG and electrolytes.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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