Drug interactions
Ribociclib + Sonidegib
Severity: Moderate
Ribociclib and Sonidegib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib is a moderate CYP3A4 inhibitor at therapeutic doses, and sonidegib is mainly cleared by CYP3A4. Sonidegib exposure may increase, raising the risk of musculoskeletal toxicity such as elevated creatine kinase and myopathy.
What this interaction means in plain words
Ribociclib and Sonidegib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ribociclib belongs to Oncology; Sonidegib belongs to Oncology.
Why it happens
Ribociclib inhibits CYP3A4, reducing sonidegib metabolism.
What to do
Monitor for muscle symptoms and check creatine kinase if symptoms appear. Consider an alternative to ribociclib if possible, or interrupt sonidegib if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Other interactions of Sonidegib
- Amiodarone + Sonidegib Major
- Apalutamide + Sonidegib Major
- Aprepitant + Sonidegib Major
- Armodafinil + Sonidegib Major
- Bosentan + Sonidegib Major
- Carbamazepine + Sonidegib Major
Frequently asked questions
Can I take Ribociclib with Sonidegib?
MediHelp rates the interaction as moderate. Ribociclib and Sonidegib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ribociclib is a moderate CYP3A4 inhibitor at therapeutic doses, and sonidegib is mainly cleared by CYP3A4. Sonidegib exposure may increase, raising the risk of musculoskeletal toxicity such as elevated creatine kinase and myopathy.
How serious is the interaction between Ribociclib and Sonidegib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for muscle symptoms and check creatine kinase if symptoms appear. Consider an alternative to ribociclib if possible, or interrupt sonidegib if toxicity occurs.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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