Drug interactions
Ribociclib + Tazemetostat
Severity: Moderate
Ribociclib and Tazemetostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib inhibits CYP3A4 and may increase tazemetostat exposure, raising the risk of its adverse effects. Tazemetostat labeling advises avoiding moderate CYP3A inhibitors or reducing the dose.
What this interaction means in plain words
Ribociclib and Tazemetostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ribociclib belongs to Oncology; Tazemetostat belongs to Miscellaneous.
Why it happens
Inhibition of CYP3A4-mediated metabolism of tazemetostat by ribociclib.
What to do
Avoid if possible; if combined, reduce the tazemetostat dose per labeling and monitor for toxicity. Restore the dose after stopping the inhibitor for about three half-lives.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Other interactions of Tazemetostat
Frequently asked questions
Can I take Ribociclib with Tazemetostat?
MediHelp rates the interaction as moderate. Ribociclib and Tazemetostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ribociclib inhibits CYP3A4 and may increase tazemetostat exposure, raising the risk of its adverse effects. Tazemetostat labeling advises avoiding moderate CYP3A inhibitors or reducing the dose.
How serious is the interaction between Ribociclib and Tazemetostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; if combined, reduce the tazemetostat dose per labeling and monitor for toxicity. Restore the dose after stopping the inhibitor for about three half-lives.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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