Drug interactions
Ribociclib + Trastuzumab deruxtecan
Severity: Moderate
Ribociclib and Trastuzumab deruxtecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents cause neutropenia, so combined use may increase the frequency and severity of neutropenia and infection. Trastuzumab deruxtecan also carries a risk of interstitial lung disease.
What this interaction means in plain words
Ribociclib and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ribociclib belongs to Oncology; Trastuzumab deruxtecan belongs to Oncology.
Why it happens
Additive myelosuppression, a pharmacodynamic interaction.
What to do
Monitor complete blood counts regularly and interrupt or reduce doses according to labeling for neutropenia; advise patients to report fever promptly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Other interactions of Trastuzumab deruxtecan
Frequently asked questions
Can I take Ribociclib with Trastuzumab deruxtecan?
MediHelp rates the interaction as moderate. Ribociclib and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents cause neutropenia, so combined use may increase the frequency and severity of neutropenia and infection. Trastuzumab deruxtecan also carries a risk of interstitial lung disease.
How serious is the interaction between Ribociclib and Trastuzumab deruxtecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts regularly and interrupt or reduce doses according to labeling for neutropenia; advise patients to report fever promptly.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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