Drug interactions
Ribociclib + Trimethoprim
Severity: Minor
Ribociclib and Trimethoprim: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trimethoprim is mainly eliminated unchanged by the kidney with only minor CYP3A4 metabolism, so ribociclib is unlikely to change its exposure meaningfully. No important clinical effect is expected.
What this interaction means in plain words
Ribociclib and Trimethoprim have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ribociclib belongs to Oncology; Trimethoprim belongs to Anti Bacterial.
Why it happens
Ribociclib inhibits CYP3A4, which is a minor metabolic pathway for trimethoprim.
What to do
No action is needed beyond routine monitoring of blood counts and potassium during therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Other interactions of Trimethoprim
Frequently asked questions
Can I take Ribociclib with Trimethoprim?
MediHelp rates the interaction as minor. Ribociclib and Trimethoprim have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Trimethoprim is mainly eliminated unchanged by the kidney with only minor CYP3A4 metabolism, so ribociclib is unlikely to change its exposure meaningfully. No important clinical effect is expected.
How serious is the interaction between Ribociclib and Trimethoprim?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is needed beyond routine monitoring of blood counts and potassium during therapy.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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