Drug interactions
Ribociclib + Velpatasvir
Severity: Minor
Ribociclib and Velpatasvir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib may modestly increase velpatasvir concentrations through CYP3A4 inhibition. Velpatasvir is well tolerated at higher exposure, so the effect is expected to be small.
What this interaction means in plain words
Ribociclib and Velpatasvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ribociclib belongs to Oncology; Velpatasvir belongs to Anti Virals.
Why it happens
Ribociclib inhibits CYP3A4, which contributes partly to velpatasvir metabolism.
What to do
No dose adjustment is needed; monitor routinely for adverse effects of both drugs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Other interactions of Velpatasvir
- Apalutamide + Velpatasvir Contraindicated
- Carbamazepine + Velpatasvir Contraindicated
- Phenytoin + Velpatasvir Contraindicated
- Bosentan + Velpatasvir Major
- Colchicine + Velpatasvir Major
- Efavirenz + Velpatasvir Major
Frequently asked questions
Can I take Ribociclib with Velpatasvir?
MediHelp rates the interaction as minor. Ribociclib and Velpatasvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ribociclib may modestly increase velpatasvir concentrations through CYP3A4 inhibition. Velpatasvir is well tolerated at higher exposure, so the effect is expected to be small.
How serious is the interaction between Ribociclib and Velpatasvir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; monitor routinely for adverse effects of both drugs.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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