Drug interactions
Rifabutin + Vilazodone
Severity: Moderate
Rifabutin and Vilazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifabutin is an inducer of CYP3A4 and can lower vilazodone plasma concentrations. Reduced exposure may lead to loss of antidepressant effect, particularly with prolonged coadministration.
What this interaction means in plain words
Rifabutin and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rifabutin belongs to Anti Bacterial; Vilazodone belongs to Central Nervous System.
Why it happens
Rifabutin induces CYP3A4, increasing the metabolic clearance of vilazodone.
What to do
Monitor for reduced antidepressant response and consider titrating vilazodone upward if the inducer is continued for more than about two weeks, staying within the labeled maximum dose. Reduce vilazodone back to the usual dose when rifabutin is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vilazodone
- Isocarboxazid + Vilazodone Contraindicated
- Methylene blue + Vilazodone Contraindicated
- Phenelzine + Vilazodone Contraindicated
- Rasagiline + Vilazodone Contraindicated
- Selegiline transdermal + Vilazodone Contraindicated
- Selegiline + Vilazodone Contraindicated
Other interactions of Rifabutin
- Cabotegravir + Rifabutin Contraindicated
- Lorlatinib + Rifabutin Contraindicated
- Rifabutin + Voriconazole Contraindicated
- Apixaban + Rifabutin Major
- Axitinib + Rifabutin Major
- Brexpiprazole + Rifabutin Major
Frequently asked questions
Can I take Rifabutin with Vilazodone?
MediHelp rates the interaction as moderate. Rifabutin and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifabutin is an inducer of CYP3A4 and can lower vilazodone plasma concentrations. Reduced exposure may lead to loss of antidepressant effect, particularly with prolonged coadministration.
How serious is the interaction between Rifabutin and Vilazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced antidepressant response and consider titrating vilazodone upward if the inducer is continued for more than about two weeks, staying within the labeled maximum dose. Reduce vilazodone back to the usual dose when rifabutin is stopped.
What other medicines interact with Vilazodone?
MediHelp also lists interactions of Vilazodone with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Vilazodone page.
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