Drug interactions
Rifampicin + Stiripentol
Severity: Major
Rifampicin and Stiripentol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampicin induces several enzymes responsible for stiripentol clearance, including CYP1A2, CYP3A4 and CYP2C19. Stiripentol concentrations may fall and seizure control may worsen.
What this interaction means in plain words
Rifampicin and Stiripentol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Rifampicin belongs to Anti Bacterial; Stiripentol belongs to Central Nervous System.
Why it happens
Induction of CYP1A2, CYP3A4 and CYP2C19 increases stiripentol metabolism.
What to do
Avoid the combination where possible. If rifampicin is required, monitor seizure frequency closely and adjust the stiripentol dose, with clinical or plasma-level guidance.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Stiripentol
Other interactions of Rifampicin
- Cabotegravir + Rifampicin Contraindicated
- Delamanid + Rifampicin Contraindicated
- Doravirine + Rifampicin Contraindicated
- Ensitrelvir + Rifampicin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
- Isavuconazole + Rifampicin Contraindicated
Frequently asked questions
Can I take Rifampicin with Stiripentol?
MediHelp rates the interaction as major. Rifampicin and Stiripentol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Rifampicin induces several enzymes responsible for stiripentol clearance, including CYP1A2, CYP3A4 and CYP2C19. Stiripentol concentrations may fall and seizure control may worsen.
How serious is the interaction between Rifampicin and Stiripentol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If rifampicin is required, monitor seizure frequency closely and adjust the stiripentol dose, with clinical or plasma-level guidance.
What other medicines interact with Stiripentol?
MediHelp also lists interactions of Stiripentol with, for example, Apalutamide, Clomipramine, Ergotamine. The full list is on the Stiripentol page.
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