Drug interactions
Rifampin + Rolapitant
Severity: Major
Rifampin and Rolapitant: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampin is a strong CYP3A4 inducer and substantially reduces rolapitant exposure. This is expected to markedly reduce antiemetic efficacy.
What this interaction means in plain words
Rifampin and Rolapitant can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Rifampin induces hepatic and intestinal CYP3A4, increasing rolapitant clearance.
What to do
Avoid concurrent use, particularly during prolonged rifampin therapy. Choose an antiemetic regimen not reliant on rolapitant if rifampin is needed.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Rolapitant
- Pimozide + Rolapitant Contraindicated
- Rolapitant + Thioridazine Contraindicated
- Atomoxetine + Rolapitant Major
- Deutetrabenazine + Rolapitant Major
- Eliglustat + Rolapitant Major
- Flecainide + Rolapitant Major
Frequently asked questions
Can I take Rifampin with Rolapitant?
MediHelp rates the interaction as major. Rifampin and Rolapitant can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Rifampin is a strong CYP3A4 inducer and substantially reduces rolapitant exposure. This is expected to markedly reduce antiemetic efficacy.
How serious is the interaction between Rifampin and Rolapitant?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use, particularly during prolonged rifampin therapy. Choose an antiemetic regimen not reliant on rolapitant if rifampin is needed.
What other medicines interact with Rolapitant?
MediHelp also lists interactions of Rolapitant with, for example, Pimozide, Thioridazine, Atomoxetine. The full list is on the Rolapitant page.
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