Drug interactions
Rifampin + Silodosin
Severity: Moderate
Rifampin and Silodosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampin is a strong inducer of CYP3A4 and P-gp, and it lowers silodosin exposure. Reduced exposure may lead to loss of symptom control.
What this interaction means in plain words
Rifampin and Silodosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Rifampin induces CYP3A4 and P-gp, increasing silodosin clearance.
What to do
Monitor urinary symptom control and consider an alternative therapy if efficacy is lost during rifampin treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Silodosin
- Atazanavir + Silodosin Contraindicated
- Conivaptan + Silodosin Contraindicated
- Darunavir + Silodosin Contraindicated
- Fosamprenavir + Silodosin Contraindicated
- Indinavir + Silodosin Contraindicated
- Itraconazole + Silodosin Contraindicated
Frequently asked questions
Can I take Rifampin with Silodosin?
MediHelp rates the interaction as moderate. Rifampin and Silodosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifampin is a strong inducer of CYP3A4 and P-gp, and it lowers silodosin exposure. Reduced exposure may lead to loss of symptom control.
How serious is the interaction between Rifampin and Silodosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor urinary symptom control and consider an alternative therapy if efficacy is lost during rifampin treatment.
What other medicines interact with Silodosin?
MediHelp also lists interactions of Silodosin with, for example, Atazanavir, Conivaptan, Darunavir. The full list is on the Silodosin page.
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