Drug interactions
Rifapentine + Ruxolitinib
Severity: Moderate
Rifapentine and Ruxolitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifapentine induces CYP3A4 and can lower ruxolitinib concentrations, potentially reducing efficacy.
What this interaction means in plain words
Rifapentine and Ruxolitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rifapentine belongs to Anti Bacterial; Ruxolitinib belongs to Oncology.
Why it happens
Rifapentine induces CYP3A4, increasing ruxolitinib clearance.
What to do
Monitor disease response and blood counts during rifapentine therapy and titrate ruxolitinib dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ruxolitinib
Other interactions of Rifapentine
- Ledipasvir-sofosbuvir + Rifapentine Contraindicated
- Lorlatinib + Rifapentine Contraindicated
- Lurasidone + Rifapentine Contraindicated
- Ranolazine + Rifapentine Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Frequently asked questions
Can I take Rifapentine with Ruxolitinib?
MediHelp rates the interaction as moderate. Rifapentine and Ruxolitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifapentine induces CYP3A4 and can lower ruxolitinib concentrations, potentially reducing efficacy.
How serious is the interaction between Rifapentine and Ruxolitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor disease response and blood counts during rifapentine therapy and titrate ruxolitinib dose as needed.
What other medicines interact with Ruxolitinib?
MediHelp also lists interactions of Ruxolitinib with, for example, Atazanavir, Ceritinib, Chloramphenicol. The full list is on the Ruxolitinib page.
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