Drug interactions
Rifapentine + Trimipramine
Severity: Moderate
Rifapentine and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifapentine induces hepatic and intestinal drug-metabolizing enzymes and can lower trimipramine plasma concentrations. This may reduce antidepressant efficacy and risk relapse. The effect can persist for some time after rifapentine is stopped.
What this interaction means in plain words
Rifapentine and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rifapentine belongs to Anti Bacterial; Trimipramine belongs to Central Nervous System.
Why it happens
Rifapentine induces CYP3A4 and other CYP enzymes, accelerating trimipramine metabolism.
What to do
Monitor clinical response and, where available, trimipramine plasma levels, and increase the dose if needed. Reduce the dose again when rifapentine is discontinued to avoid toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Other interactions of Rifapentine
- Ledipasvir-sofosbuvir + Rifapentine Contraindicated
- Lorlatinib + Rifapentine Contraindicated
- Lurasidone + Rifapentine Contraindicated
- Ranolazine + Rifapentine Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Frequently asked questions
Can I take Rifapentine with Trimipramine?
MediHelp rates the interaction as moderate. Rifapentine and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifapentine induces hepatic and intestinal drug-metabolizing enzymes and can lower trimipramine plasma concentrations. This may reduce antidepressant efficacy and risk relapse. The effect can persist for some time after rifapentine is stopped.
How serious is the interaction between Rifapentine and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and, where available, trimipramine plasma levels, and increase the dose if needed. Reduce the dose again when rifapentine is discontinued to avoid toxicity.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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