Drug interactions
Rilonacept + Sirolimus
Severity: Moderate
Rilonacept and Sirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rilonacept blocks interleukin-1 signalling and, together with sirolimus, may increase susceptibility to infection. Clinical data on the combination are limited.
What this interaction means in plain words
Rilonacept and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rilonacept belongs to Miscellaneous; Sirolimus belongs to Miscellaneous.
Why it happens
Additive immunosuppression through IL-1 blockade and mTOR inhibition.
What to do
Monitor for signs of infection and screen for latent infections beforehand. Interrupt rilonacept if a serious infection develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Other interactions of Rilonacept
Frequently asked questions
Can I take Rilonacept with Sirolimus?
MediHelp rates the interaction as moderate. Rilonacept and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rilonacept blocks interleukin-1 signalling and, together with sirolimus, may increase susceptibility to infection. Clinical data on the combination are limited.
How serious is the interaction between Rilonacept and Sirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of infection and screen for latent infections beforehand. Interrupt rilonacept if a serious infection develops.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
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