Drug interactions
Rilonacept + Tacrolimus
Severity: Moderate
Rilonacept and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs suppress the immune system, and combining them may raise the risk of serious infection. Interleukin-1 blockade adds to calcineurin inhibitor immunosuppression.
What this interaction means in plain words
Rilonacept and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rilonacept belongs to Miscellaneous; Tacrolimus belongs to Miscellaneous.
Why it happens
Additive immunosuppression via IL-1 blockade and calcineurin inhibition.
What to do
Monitor for signs of infection and delay rilonacept if an active infection develops. Do not give live vaccines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Rilonacept and Tacrolimus, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Other interactions of Rilonacept
Frequently asked questions
Can I take Rilonacept with Tacrolimus?
MediHelp rates the interaction as moderate. Rilonacept and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs suppress the immune system, and combining them may raise the risk of serious infection. Interleukin-1 blockade adds to calcineurin inhibitor immunosuppression.
How serious is the interaction between Rilonacept and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of infection and delay rilonacept if an active infection develops. Do not give live vaccines.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
