Drug interactions
Rilpivirine + Tecovirimat
Severity: Moderate
Rilpivirine and Tecovirimat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tecovirimat may lower rilpivirine concentrations, risking reduced antiviral efficacy and virologic failure in HIV. The effect is predicted from enzyme induction.
What this interaction means in plain words
Rilpivirine and Tecovirimat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rilpivirine belongs to Anti Virals; Tecovirimat belongs to Miscellaneous.
Why it happens
Tecovirimat is a weak inducer of CYP3A (and CYP2B6), increasing rilpivirine metabolism.
What to do
Monitor HIV viral load and clinical response during and after the tecovirimat course. Ensure rilpivirine is taken with a meal.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tecovirimat
- Bosentan + Tecovirimat Moderate
- Cyclosporin + Tecovirimat Moderate
- Darunavir + Tecovirimat Moderate
- Ethinyl estradiol-drospirenone + Tecovirimat Moderate
- Ethinyl estradiol-levonorgestrel + Tecovirimat Moderate
- Glimepiride-pioglitazone + Tecovirimat Moderate
Other interactions of Rilpivirine
- Carbamazepine + Rilpivirine Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Efavirenz + Rilpivirine Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Esomeprazole + Rilpivirine Contraindicated
Frequently asked questions
Can I take Rilpivirine with Tecovirimat?
MediHelp rates the interaction as moderate. Rilpivirine and Tecovirimat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tecovirimat may lower rilpivirine concentrations, risking reduced antiviral efficacy and virologic failure in HIV. The effect is predicted from enzyme induction.
How serious is the interaction between Rilpivirine and Tecovirimat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor HIV viral load and clinical response during and after the tecovirimat course. Ensure rilpivirine is taken with a meal.
What other medicines interact with Tecovirimat?
MediHelp also lists interactions of Tecovirimat with, for example, Bosentan, Cyclosporin, Darunavir. The full list is on the Tecovirimat page.
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