Drug interactions
Rilpivirine + Voriconazole
Severity: Moderate
Rilpivirine and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole may raise rilpivirine concentrations, and both drugs can prolong the QT interval. Rilpivirine may also modestly alter voriconazole exposure. The main concern is additive QT prolongation at higher rilpivirine concentrations.
What this interaction means in plain words
Rilpivirine and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rilpivirine belongs to Anti Virals; Voriconazole belongs to Anti Fungals.
Why it happens
Voriconazole inhibits CYP3A4 metabolism of rilpivirine, with additive QT prolongation.
What to do
No rilpivirine dose change is required. Consider an ECG in patients with QT risk factors and monitor for breakthrough fungal infection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Rilpivirine
- Carbamazepine + Rilpivirine Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Efavirenz + Rilpivirine Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Esomeprazole + Rilpivirine Contraindicated
Frequently asked questions
Can I take Rilpivirine with Voriconazole?
MediHelp rates the interaction as moderate. Rilpivirine and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voriconazole may raise rilpivirine concentrations, and both drugs can prolong the QT interval. Rilpivirine may also modestly alter voriconazole exposure. The main concern is additive QT prolongation at higher rilpivirine concentrations.
How serious is the interaction between Rilpivirine and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No rilpivirine dose change is required. Consider an ECG in patients with QT risk factors and monitor for breakthrough fungal infection.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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