Drug interactions
Rimegepant + Tacrolimus
Severity: Moderate
Rimegepant and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tacrolimus inhibits P-glycoprotein and may increase rimegepant exposure. Higher rimegepant levels could increase adverse effects such as nausea and hypersensitivity.
What this interaction means in plain words
Rimegepant and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rimegepant belongs to Central Nervous System; Tacrolimus belongs to Miscellaneous.
Why it happens
P-glycoprotein inhibition by tacrolimus reduces rimegepant efflux and increases its absorption.
What to do
Avoid a second rimegepant dose within 48 hours when it is taken with a P-gp inhibitor, per labeling. Monitor for adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Other interactions of Rimegepant
Frequently asked questions
Can I take Rimegepant with Tacrolimus?
MediHelp rates the interaction as moderate. Rimegepant and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tacrolimus inhibits P-glycoprotein and may increase rimegepant exposure. Higher rimegepant levels could increase adverse effects such as nausea and hypersensitivity.
How serious is the interaction between Rimegepant and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid a second rimegepant dose within 48 hours when it is taken with a P-gp inhibitor, per labeling. Monitor for adverse effects.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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