Drug interactions
Rimegepant + Velpatasvir
Severity: Moderate
Rimegepant and Velpatasvir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Velpatasvir inhibits P-glycoprotein and may raise rimegepant absorption. The clinical effect is likely modest but may increase side effects.
What this interaction means in plain words
Rimegepant and Velpatasvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rimegepant belongs to Central Nervous System; Velpatasvir belongs to Anti Virals.
Why it happens
Velpatasvir inhibits intestinal P-gp efflux of rimegepant.
What to do
Avoid repeat rimegepant dosing within 48 hours and monitor for adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rimegepant
Other interactions of Velpatasvir
- Apalutamide + Velpatasvir Contraindicated
- Carbamazepine + Velpatasvir Contraindicated
- Phenytoin + Velpatasvir Contraindicated
- Bosentan + Velpatasvir Major
- Colchicine + Velpatasvir Major
- Efavirenz + Velpatasvir Major
Frequently asked questions
Can I take Rimegepant with Velpatasvir?
MediHelp rates the interaction as moderate. Rimegepant and Velpatasvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Velpatasvir inhibits P-glycoprotein and may raise rimegepant absorption. The clinical effect is likely modest but may increase side effects.
How serious is the interaction between Rimegepant and Velpatasvir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid repeat rimegepant dosing within 48 hours and monitor for adverse effects.
What other medicines interact with Rimegepant?
MediHelp also lists interactions of Rimegepant with, for example, Amobarbital, Atazanavir, Butabarbital. The full list is on the Rimegepant page.
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