Drug interactions
Rimegepant + Vemurafenib
Severity: Moderate
Rimegepant and Vemurafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vemurafenib inhibits P-gp and may increase rimegepant exposure, though it also induces CYP3A4, making the net effect uncertain.
What this interaction means in plain words
Rimegepant and Vemurafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rimegepant belongs to Central Nervous System; Vemurafenib belongs to Oncology.
Why it happens
Vemurafenib inhibits P-gp efflux of rimegepant and may weakly induce CYP3A4.
What to do
Avoid repeat rimegepant dosing within 48 hours and monitor for both adverse effects and loss of efficacy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rimegepant
Other interactions of Vemurafenib
Frequently asked questions
Can I take Rimegepant with Vemurafenib?
MediHelp rates the interaction as moderate. Rimegepant and Vemurafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vemurafenib inhibits P-gp and may increase rimegepant exposure, though it also induces CYP3A4, making the net effect uncertain.
How serious is the interaction between Rimegepant and Vemurafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid repeat rimegepant dosing within 48 hours and monitor for both adverse effects and loss of efficacy.
What other medicines interact with Rimegepant?
MediHelp also lists interactions of Rimegepant with, for example, Amobarbital, Atazanavir, Butabarbital. The full list is on the Rimegepant page.
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