Drug interactions
Ripretinib + Voriconazole
Severity: Moderate
Ripretinib and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole is a strong CYP3A4 inhibitor and can raise exposure to ripretinib and its active metabolite. This may increase the frequency or severity of ripretinib adverse effects such as palmar-plantar erythrodysesthesia, hypertension and fatigue.
What this interaction means in plain words
Ripretinib and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ripretinib belongs to Oncology; Voriconazole belongs to Anti Fungals.
Why it happens
Voriconazole inhibits CYP3A4-mediated metabolism of ripretinib and its active metabolite.
What to do
Monitor for ripretinib adverse reactions and consider an alternative azole or antifungal with weaker CYP3A4 inhibition where possible. Reduce or interrupt ripretinib if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Ripretinib
- Amobarbital + Ripretinib Major
- Apalutamide + Ripretinib Major
- Carbamazepine + Ripretinib Major
- Efavirenz + Ripretinib Major
- Enzalutamide + Ripretinib Major
- Phenytoin + Ripretinib Major
Frequently asked questions
Can I take Ripretinib with Voriconazole?
MediHelp rates the interaction as moderate. Ripretinib and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voriconazole is a strong CYP3A4 inhibitor and can raise exposure to ripretinib and its active metabolite. This may increase the frequency or severity of ripretinib adverse effects such as palmar-plantar erythrodysesthesia, hypertension and fatigue.
How serious is the interaction between Ripretinib and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for ripretinib adverse reactions and consider an alternative azole or antifungal with weaker CYP3A4 inhibition where possible. Reduce or interrupt ripretinib if toxicity develops.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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