Drug interactions
Risperidone + Ritonavir
Severity: Major
Risperidone and Ritonavir: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir inhibits CYP3A4, CYP2D6 and P-glycoprotein and can raise risperidone exposure. This increases the risk of sedation, extrapyramidal symptoms, hypotension and QT effects.
What this interaction means in plain words
Risperidone and Ritonavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Risperidone belongs to Central Nervous System; Ritonavir belongs to Anti Virals.
Why it happens
Inhibition of CYP3A4, CYP2D6 and P-glycoprotein reduces risperidone clearance.
What to do
Start risperidone at a low dose and titrate carefully, monitoring for extrapyramidal symptoms, sedation and hypotension. Reduce the dose if adverse effects appear.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Other interactions of Ritonavir
- Alfuzosin + Ritonavir Contraindicated
- Amiodarone + Ritonavir Contraindicated
- Avanafil + Ritonavir Contraindicated
- Colchicine + Ritonavir Contraindicated
- Dronedarone + Ritonavir Contraindicated
- Eletriptan + Ritonavir Contraindicated
Frequently asked questions
Can I take Risperidone with Ritonavir?
MediHelp rates the interaction as major. Risperidone and Ritonavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ritonavir inhibits CYP3A4, CYP2D6 and P-glycoprotein and can raise risperidone exposure. This increases the risk of sedation, extrapyramidal symptoms, hypotension and QT effects.
How serious is the interaction between Risperidone and Ritonavir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start risperidone at a low dose and titrate carefully, monitoring for extrapyramidal symptoms, sedation and hypotension. Reduce the dose if adverse effects appear.
What other medicines interact with Risperidone?
MediHelp also lists interactions of Risperidone with, for example, Ibutilide, Vandetanib, Adagrasib. The full list is on the Risperidone page.
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