Drug interactions
Risperidone + Saxagliptin-metformin
Severity: Moderate
Risperidone and Saxagliptin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Risperidone may cause weight gain and hyperglycemia, which can reduce the effectiveness of both components of saxagliptin-metformin. Glycemic control can deteriorate in diabetic patients.
What this interaction means in plain words
Risperidone and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Risperidone belongs to Central Nervous System; Saxagliptin-metformin belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism through antipsychotic-associated insulin resistance and weight gain.
What to do
Monitor fasting glucose and HbA1c after starting risperidone and periodically afterward. Intensify antidiabetic therapy if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Saxagliptin-metformin
Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Frequently asked questions
Can I take Risperidone with Saxagliptin-metformin?
MediHelp rates the interaction as moderate. Risperidone and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Risperidone may cause weight gain and hyperglycemia, which can reduce the effectiveness of both components of saxagliptin-metformin. Glycemic control can deteriorate in diabetic patients.
How serious is the interaction between Risperidone and Saxagliptin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fasting glucose and HbA1c after starting risperidone and periodically afterward. Intensify antidiabetic therapy if needed.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
Full monographs, dosing and an interaction checker in the MediHelp app
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