Drug interactions
risperidone + sertraline
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Sertraline (moderate CYP2D6 inhibitor) may increase risperidone exposure and both can prolong QTc, raising risk of EPS/sedation and torsades in susceptible patients.
Mechanism of action
CYP2D6 inhibition by sertraline → ↑ risperidone concentrations; both agents have QT‑prolonging potential → additive QTc effects.
Clinical management
Use lowest effective risperidone dose; monitor for EPS, sedation, orthostasis after starting or increasing sertraline; consider baseline/follow‑up ECG if cardiac risk factors; avoid other QT‑prolongers; correct K/Mg.
Drug reference
References
- Risperidone (Risperdal) Prescribing Information – Drug Interactions — FDA Label
- Sertraline (Zoloft) Prescribing Information – Drug Interactions — FDA Label
- QTDrugs Lists: Risperidone; Sertraline — CredibleMeds
Frequently asked questions
Can I take risperidone with sertraline?
The interaction is rated: Moderate. Sertraline (moderate CYP2D6 inhibitor) may increase risperidone exposure and both can prolong QTc, raising risk of EPS/sedation and torsades in susceptible patients.
How serious is the interaction between risperidone and sertraline?
The interaction is rated: Moderate. Evidence level: Moderate.
How is the interaction between risperidone and sertraline managed?
Use lowest effective risperidone dose; monitor for EPS, sedation, orthostasis after starting or increasing sertraline; consider baseline/follow‑up ECG if cardiac risk factors; avoid other QT‑prolongers; correct K/Mg.
Why do risperidone and sertraline interact?
CYP2D6 inhibition by sertraline → ↑ risperidone concentrations; both agents have QT‑prolonging potential → additive QTc effects.
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