Drug interactions
Risperidone + Sitagliptin
Severity: Moderate
Risperidone and Sitagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Risperidone can cause hyperglycemia and impaired glucose tolerance, which may offset the glucose-lowering action of sitagliptin. Glycemic control may deteriorate in patients with diabetes.
What this interaction means in plain words
Risperidone and Sitagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Risperidone belongs to Central Nervous System; Sitagliptin belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism: risperidone can induce insulin resistance and weight gain, opposing the antihyperglycemic effect of sitagliptin.
What to do
Monitor fasting glucose and HbA1c when risperidone is started or the dose changed. Adjust the antidiabetic regimen as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Other interactions of Sitagliptin
- Albiglutide + Sitagliptin Moderate
- Amlodipine-benazepril + Sitagliptin Moderate
- Aripiprazole + Sitagliptin Moderate
- Asenapine + Sitagliptin Moderate
- Benazepril + Sitagliptin Moderate
- Captopril-hydrochlorothiazide + Sitagliptin Moderate
Frequently asked questions
Can I take Risperidone with Sitagliptin?
MediHelp rates the interaction as moderate. Risperidone and Sitagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Risperidone can cause hyperglycemia and impaired glucose tolerance, which may offset the glucose-lowering action of sitagliptin. Glycemic control may deteriorate in patients with diabetes.
How serious is the interaction between Risperidone and Sitagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fasting glucose and HbA1c when risperidone is started or the dose changed. Adjust the antidiabetic regimen as needed.
What other medicines interact with Risperidone?
MediHelp also lists interactions of Risperidone with, for example, Ibutilide, Vandetanib, Adagrasib. The full list is on the Risperidone page.
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