Drug interactions
Risperidone + Terbinafine
Severity: Moderate
Risperidone and Terbinafine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Risperidone is converted to active 9-hydroxyrisperidone by CYP2D6. Terbinafine can raise risperidone levels and shift the parent-to-metabolite ratio, which may increase extrapyramidal effects, sedation and hypotension.
What this interaction means in plain words
Risperidone and Terbinafine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Risperidone belongs to Central Nervous System; Terbinafine belongs to Anti Fungals.
Why it happens
Terbinafine inhibits CYP2D6-mediated conversion of risperidone to 9-hydroxyrisperidone.
What to do
Monitor for extrapyramidal symptoms, sedation and orthostasis. Reduce the risperidone dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Terbinafine
- Terbinafine + Thioridazine Contraindicated
- Desipramine + Terbinafine Major
- Eliglustat + Terbinafine Major
- Flecainide + Terbinafine Major
- Imipramine + Terbinafine Major
- Maprotiline + Terbinafine Major
Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Frequently asked questions
Can I take Risperidone with Terbinafine?
MediHelp rates the interaction as moderate. Risperidone and Terbinafine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Risperidone is converted to active 9-hydroxyrisperidone by CYP2D6. Terbinafine can raise risperidone levels and shift the parent-to-metabolite ratio, which may increase extrapyramidal effects, sedation and hypotension.
How serious is the interaction between Risperidone and Terbinafine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for extrapyramidal symptoms, sedation and orthostasis. Reduce the risperidone dose if needed.
What other medicines interact with Terbinafine?
MediHelp also lists interactions of Terbinafine with, for example, Thioridazine, Desipramine, Eliglustat. The full list is on the Terbinafine page.
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