Drug interactions
Risperidone + Tolazamide
Severity: Moderate
Risperidone and Tolazamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Risperidone may cause hyperglycemia and weight gain, which can reduce the effectiveness of sulfonylureas such as tolazamide. Glycemic control may worsen in diabetic patients.
What this interaction means in plain words
Risperidone and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Risperidone belongs to Central Nervous System; Tolazamide belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism through antipsychotic-induced insulin resistance and impaired glucose regulation.
What to do
Monitor blood glucose and HbA1c after starting or changing risperidone. Titrate the tolazamide dose or alter the antidiabetic regimen as required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Frequently asked questions
Can I take Risperidone with Tolazamide?
MediHelp rates the interaction as moderate. Risperidone and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Risperidone may cause hyperglycemia and weight gain, which can reduce the effectiveness of sulfonylureas such as tolazamide. Glycemic control may worsen in diabetic patients.
How serious is the interaction between Risperidone and Tolazamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting or changing risperidone. Titrate the tolazamide dose or alter the antidiabetic regimen as required.
What other medicines interact with Risperidone?
MediHelp also lists interactions of Risperidone with, for example, Ibutilide, Vandetanib, Adagrasib. The full list is on the Risperidone page.
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