Drug interactions
Risperidone + Tolbutamide
Severity: Moderate
Risperidone and Tolbutamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Risperidone may raise blood glucose and promote weight gain, potentially counteracting tolbutamide. Diabetic control may deteriorate.
What this interaction means in plain words
Risperidone and Tolbutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Risperidone belongs to Central Nervous System; Tolbutamide belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism through antipsychotic-induced insulin resistance and impaired glucose regulation.
What to do
Monitor fasting glucose and HbA1c regularly. Adjust tolbutamide dose or add other therapy if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Other interactions of Tolbutamide
- Glyburide-metformin + Tolbutamide Major
- Insulin degludec-liraglutide + Tolbutamide Major
- Aceclofenac + Tolbutamide Moderate
- Acemetacin + Tolbutamide Moderate
- Acetylsalicylic acid + Tolbutamide Moderate
- Albiglutide + Tolbutamide Moderate
Frequently asked questions
Can I take Risperidone with Tolbutamide?
MediHelp rates the interaction as moderate. Risperidone and Tolbutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Risperidone may raise blood glucose and promote weight gain, potentially counteracting tolbutamide. Diabetic control may deteriorate.
How serious is the interaction between Risperidone and Tolbutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fasting glucose and HbA1c regularly. Adjust tolbutamide dose or add other therapy if control worsens.
What other medicines interact with Risperidone?
MediHelp also lists interactions of Risperidone with, for example, Ibutilide, Vandetanib, Adagrasib. The full list is on the Risperidone page.
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