Drug interactions
Risperidone + Verapamil
Severity: Moderate
Risperidone and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil may modestly increase risperidone exposure, leading to more sedation, orthostasis and extrapyramidal effects. Additive hypotension is possible.
What this interaction means in plain words
Risperidone and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Risperidone belongs to Central Nervous System; Verapamil belongs to Cardiovascular.
Why it happens
Verapamil inhibits P-glycoprotein efflux of risperidone and its active metabolite.
What to do
Monitor blood pressure and extrapyramidal symptoms. Lower the risperidone dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Frequently asked questions
Can I take Risperidone with Verapamil?
MediHelp rates the interaction as moderate. Risperidone and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Verapamil may modestly increase risperidone exposure, leading to more sedation, orthostasis and extrapyramidal effects. Additive hypotension is possible.
How serious is the interaction between Risperidone and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and extrapyramidal symptoms. Lower the risperidone dose if adverse effects occur.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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