Drug interactions
Ritlecitinib + Sirolimus
Severity: Moderate
Ritlecitinib and Sirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritlecitinib inhibits CYP3A4 and may increase exposure to sirolimus. Both drugs also suppress immune function, adding to infection risk.
What this interaction means in plain words
Ritlecitinib and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ritlecitinib belongs to Oncology; Sirolimus belongs to Miscellaneous.
Why it happens
Ritlecitinib inhibits CYP3A4 metabolism of sirolimus; there is also additive immunosuppression.
What to do
Monitor sirolimus trough levels and adjust the dose, and monitor for infection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Other interactions of Ritlecitinib
Frequently asked questions
Can I take Ritlecitinib with Sirolimus?
MediHelp rates the interaction as moderate. Ritlecitinib and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ritlecitinib inhibits CYP3A4 and may increase exposure to sirolimus. Both drugs also suppress immune function, adding to infection risk.
How serious is the interaction between Ritlecitinib and Sirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sirolimus trough levels and adjust the dose, and monitor for infection.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
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