Drug interactions
Ritlecitinib + Tacrolimus
Severity: Moderate
Ritlecitinib and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritlecitinib may raise tacrolimus exposure, and the combination also adds immunosuppression, which increases infection risk. Higher tacrolimus levels can cause nephrotoxicity and neurotoxicity.
What this interaction means in plain words
Ritlecitinib and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ritlecitinib belongs to Oncology; Tacrolimus belongs to Miscellaneous.
Why it happens
Ritlecitinib inhibits CYP3A4, reducing tacrolimus metabolism, and it adds pharmacodynamic immunosuppression.
What to do
Monitor tacrolimus trough concentrations and renal function after starting ritlecitinib and adjust the dose. Watch for infection; concurrent use with potent immunosuppressants is generally avoided.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Other interactions of Ritlecitinib
Frequently asked questions
Can I take Ritlecitinib with Tacrolimus?
MediHelp rates the interaction as moderate. Ritlecitinib and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ritlecitinib may raise tacrolimus exposure, and the combination also adds immunosuppression, which increases infection risk. Higher tacrolimus levels can cause nephrotoxicity and neurotoxicity.
How serious is the interaction between Ritlecitinib and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tacrolimus trough concentrations and renal function after starting ritlecitinib and adjust the dose. Watch for infection; concurrent use with potent immunosuppressants is generally avoided.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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