Drug interactions
Ritonavir + Tiotropium-olodaterol
Severity: Moderate
Ritonavir and Tiotropium-olodaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir can prolong the QT interval at higher exposure and strongly inhibits CYP3A4. With olodaterol, additive effects on cardiac repolarization and heart rate are possible, though inhaled exposure is low.
What this interaction means in plain words
Ritonavir and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ritonavir belongs to Anti Virals; Tiotropium-olodaterol belongs to Respiratory.
Why it happens
Additive QT prolongation, with possible CYP3A4/P-gp inhibition raising olodaterol exposure.
What to do
Monitor for palpitations and arrhythmias and check ECG in patients with other QT risk factors. Keep potassium and magnesium normal.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium-olodaterol
Other interactions of Ritonavir
- Alfuzosin + Ritonavir Contraindicated
- Amiodarone + Ritonavir Contraindicated
- Avanafil + Ritonavir Contraindicated
- Colchicine + Ritonavir Contraindicated
- Dronedarone + Ritonavir Contraindicated
- Eletriptan + Ritonavir Contraindicated
Frequently asked questions
Can I take Ritonavir with Tiotropium-olodaterol?
MediHelp rates the interaction as moderate. Ritonavir and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ritonavir can prolong the QT interval at higher exposure and strongly inhibits CYP3A4. With olodaterol, additive effects on cardiac repolarization and heart rate are possible, though inhaled exposure is low.
How serious is the interaction between Ritonavir and Tiotropium-olodaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for palpitations and arrhythmias and check ECG in patients with other QT risk factors. Keep potassium and magnesium normal.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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