Drug interactions
Ritonavir + Vortioxetine
Severity: Moderate
Ritonavir and Vortioxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir inhibits CYP2D6 and CYP3A4, which may raise vortioxetine exposure and increase nausea and other adverse effects. Ritonavir can also induce some enzymes with prolonged use, so the net effect varies.
What this interaction means in plain words
Ritonavir and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ritonavir belongs to Anti Virals; Vortioxetine belongs to Central Nervous System.
Why it happens
Inhibition of CYP2D6 and CYP3A4 by ritonavir reduces vortioxetine clearance.
What to do
Consider halving the vortioxetine dose when a strong CYP2D6 inhibitor is started and monitor tolerability. Restore the usual dose after the inhibitor is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Other interactions of Ritonavir
- Alfuzosin + Ritonavir Contraindicated
- Amiodarone + Ritonavir Contraindicated
- Avanafil + Ritonavir Contraindicated
- Colchicine + Ritonavir Contraindicated
- Dronedarone + Ritonavir Contraindicated
- Eletriptan + Ritonavir Contraindicated
Frequently asked questions
Can I take Ritonavir with Vortioxetine?
MediHelp rates the interaction as moderate. Ritonavir and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ritonavir inhibits CYP2D6 and CYP3A4, which may raise vortioxetine exposure and increase nausea and other adverse effects. Ritonavir can also induce some enzymes with prolonged use, so the net effect varies.
How serious is the interaction between Ritonavir and Vortioxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider halving the vortioxetine dose when a strong CYP2D6 inhibitor is started and monitor tolerability. Restore the usual dose after the inhibitor is stopped.
What other medicines interact with Vortioxetine?
MediHelp also lists interactions of Vortioxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Vortioxetine page.
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