Drug interactions
Rivaroxaban + Tazemetostat
Severity: Moderate
Rivaroxaban and Tazemetostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tazemetostat is a weak-to-moderate CYP3A4 inducer and may modestly reduce rivaroxaban exposure. This could reduce anticoagulant efficacy.
What this interaction means in plain words
Rivaroxaban and Tazemetostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rivaroxaban belongs to Cardiovascular; Tazemetostat belongs to Miscellaneous.
Why it happens
Induction of CYP3A4 increases rivaroxaban metabolism.
What to do
Monitor for signs of thrombosis and consider an alternative anticoagulant if efficacy is a concern.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rivaroxaban
- Defibrotide + Rivaroxaban Contraindicated
- Ketoconazole + Rivaroxaban Contraindicated
- Ketorolac + Rivaroxaban Contraindicated
- Abciximab + Rivaroxaban Major
- Acalabrutinib + Rivaroxaban Major
- Acetylsalicylic acid + Rivaroxaban Major
Other interactions of Tazemetostat
Frequently asked questions
Can I take Rivaroxaban with Tazemetostat?
MediHelp rates the interaction as moderate. Rivaroxaban and Tazemetostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tazemetostat is a weak-to-moderate CYP3A4 inducer and may modestly reduce rivaroxaban exposure. This could reduce anticoagulant efficacy.
How serious is the interaction between Rivaroxaban and Tazemetostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of thrombosis and consider an alternative anticoagulant if efficacy is a concern.
What other medicines interact with Rivaroxaban?
MediHelp also lists interactions of Rivaroxaban with, for example, Defibrotide, Ketoconazole, Ketorolac. The full list is on the Rivaroxaban page.
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