Drug interactions
Rivaroxaban + Vemurafenib
Severity: Moderate
Rivaroxaban and Vemurafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vemurafenib inhibits P-glycoprotein and may modestly raise rivaroxaban concentrations. This could increase bleeding risk.
What this interaction means in plain words
Rivaroxaban and Vemurafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rivaroxaban belongs to Cardiovascular; Vemurafenib belongs to Oncology.
Why it happens
Inhibition of P-gp efflux increases rivaroxaban absorption and reduces its clearance.
What to do
Monitor for bleeding, particularly in patients with renal impairment or other bleeding risks.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rivaroxaban
- Defibrotide + Rivaroxaban Contraindicated
- Ketoconazole + Rivaroxaban Contraindicated
- Ketorolac + Rivaroxaban Contraindicated
- Abciximab + Rivaroxaban Major
- Acalabrutinib + Rivaroxaban Major
- Acetylsalicylic acid + Rivaroxaban Major
Other interactions of Vemurafenib
Frequently asked questions
Can I take Rivaroxaban with Vemurafenib?
MediHelp rates the interaction as moderate. Rivaroxaban and Vemurafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vemurafenib inhibits P-glycoprotein and may modestly raise rivaroxaban concentrations. This could increase bleeding risk.
How serious is the interaction between Rivaroxaban and Vemurafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding, particularly in patients with renal impairment or other bleeding risks.
What other medicines interact with Rivaroxaban?
MediHelp also lists interactions of Rivaroxaban with, for example, Defibrotide, Ketoconazole, Ketorolac. The full list is on the Rivaroxaban page.
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