Drug interactions
Roflumilast + Rucaparib
Severity: Minor
Roflumilast and Rucaparib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib is a moderate CYP3A4 inhibitor in vitro and may modestly increase roflumilast exposure. It also inhibits CYP1A2, which contributes to roflumilast metabolism, so adverse effects could be amplified.
What this interaction means in plain words
Roflumilast and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Roflumilast belongs to Respiratory; Rucaparib belongs to Oncology.
Why it happens
Rucaparib inhibits CYP1A2 and CYP3A4, reducing roflumilast clearance.
What to do
Monitor for diarrhea, weight loss, insomnia and psychiatric symptoms. Reassess roflumilast tolerability if adverse effects emerge.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Roflumilast
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Roflumilast with Rucaparib?
MediHelp rates the interaction as minor. Roflumilast and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rucaparib is a moderate CYP3A4 inhibitor in vitro and may modestly increase roflumilast exposure. It also inhibits CYP1A2, which contributes to roflumilast metabolism, so adverse effects could be amplified.
How serious is the interaction between Roflumilast and Rucaparib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for diarrhea, weight loss, insomnia and psychiatric symptoms. Reassess roflumilast tolerability if adverse effects emerge.
What other medicines interact with Roflumilast?
MediHelp also lists interactions of Roflumilast with, for example, Apalutamide, Carbamazepine, Efavirenz. The full list is on the Roflumilast page.
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